Physics of Biology

2205 Submissions

[2] viXra:2205.0118 [pdf] submitted on 2022-05-22 21:21:16

Wilyman Report on Vaccines: How do we Handle the next Pandemic, Small, Large or ‘Predicted’?

Authors: Edward J Steele
Comments: 13 Pages.

Censorship and Active Suppression of Science and Medicine: Censorship exercised on scale during the Covid-19 pandemic has actively suppressed the wide circulation of legitimate scientific inquiry, critical analysis and discussion. Together with the vaccination failure itself, as foreshadow by Judy Wilyman, the officially sanctioned censorship is now the No.1 issue of our time. It has involved the lockstep behaviour of BigPharma, main stream media, BigTech, governments, peak medical, scientific and public health authorities. How did this happen? What are the well spring roots of this extraordinary co-ordinated active suppression of legitimate alternative viewpoints and data analysis in science and medicine?
Category: Physics of Biology

[1] viXra:2205.0073 [pdf] submitted on 2022-05-13 20:16:46

A Protein Hydrophilic Active Site Could by Mutual Exclusion Became Hydrophobic, Allowing This Vectorial Transition to Bypass the Microscopic Reversibility Principle

Authors: Alfred Bennun
Comments: 22 Pages. 9 figures

Prigogine proposed a coupling between larger sources of enthalpy to allow an open system to operate life. The sun flow of energy is coupled to water cluster thermogenic breakdown of H-bonds to vapor. The position of proline in a polypeptide chain allows sliding between segments, in the tertiary folding structure response to electrostatic attractions, could differentiate positive vs negative domains. Thus, bypass the microscopic reversibility principle, illustrated as a single door, vectorial kinetic only made possible by the jokingly Maxwell proposed operator demons. The physiological function of Hb oxygenation by pO_2 shows a microscopic thermogenesis biological vector, functioning by the enthalpy potential of the large mass action of surrounding air and releasing entropy. The mechanism shows the H-bonds breakdown required for changes in the structure-function levels by the proline mediated folding. The tense (T) to relax (R) forms shows vectorial microscopic dynamics, during Hb oxygenation. Thus involves a sliding by H-bonds breakdown, distancing between subunits β_2 and α_1. Thus, open a larger entrance to a fully hydrated Mg^2+ to coordinate amphoteric and negative R groups characterizable to a hydrophilic site. The transition of R to T allows positive R groups to bind 2,3-DPG to form deoxyHb. Thus, a microscopic smaller entrance by decreasing its opening size does not allow entrance of the fully hydrated Mg2+, but allow the exit of nitric oxide (NO) and a poorly hydrated Mg^2+, denominated nascent. This one acts for competitive hydration sieving on the shells of Na+, which in terms take water from the K+ shell, potentiating a K+/Na+-translocation operating the electrogenic transmembrane potential. The deoxygenation in the reverse transition of R to T binds NO, protecting against a premature decrease of the chromosome’s telomeres size by stressing factors such as depression, anxiety and physic traumatisms, over endothelial cells delaying premature senescence. The arginine metabolism produces NO, dilating blood vessels, improving the circulatory systems and the muscular recovery-development. A diet rich in arginine by producing a high sustainable level of NO may prevent the resistance to treatment by the consolidation of large vascular masses. The H-bonds donor potential by their breakdown leads to randomness (or entropy) decreasing the kinetic energy of solvation, scaling down the polarity on the thermogenic dissipation of oxy vs deoxyHb and choroid plexus epithelium on plasma generation of cerebrospinal fluid (CSF). The enthalpy of photosynthesis-metabolism releases CO_2, whereas the water cluster mediated thermostatic function releases vapor. In both systems, the entropy release maintains a high potential of enthalpy. Hence, overcomes the thermic and electric noises by an irreversible dissipative kinetics, facilitating a clear development of a meditative level of reasoning and learning. Thus, the brain acquires an autonomous function, beyond behavioral genetic conditioning.
Category: Physics of Biology